Jonathan Katz, M.D.

 

Dr. Katz studies amyotrophic lateral sclerosis (ALS), myasthenia gravis, neuromuscular diseases, pain management, peripheral neuropathy, poliomyelitis, radiculopathies, and spinal muscular atrophy. He leads clinical trials of pharmacotherapies to slow the progression of ALS; device trials; a study of the NeuRX Diaphragm Pacing System to support patients with diaphragm weakness; and observational studies of factors affecting disease progression.  Dr. Katz and others at the Forbes Norris Center work with researchers at the University of California, San Diego, to study mutations in RNA binding proteins that cause neuronal dysfunction and death. In 2014, Dr. Katz and colleagues at CPMC will collaborate with Cedars-Sinai Regenerative Medicine Institute on new stem cell and gene therapy techniques to treat ALS patients. He is President of the ALS Research Group—an international ALS research collaboration. He sits on the medical advisory board for GBS-CIDP Foundation.

Dr. Bowser

Robert Bowser, PhD

 

Dr. Robert Bowser is an internationally recognized leader in ALS research. He has contributed to pioneering efforts to discover and validate biomarkers for ALS. These biomarkers can be useful as diagnostic indicators of disease, predictors of disease progression, and in determining the effectiveness of drugs in clinical trials. Dr. Bowser has extensive experience in the translation of basic science discoveries to the clinic to impact patient care.  As director of the ALS Research Center, Dr. Bowser directs research to determine the underlying mechanisms of ALS, identify new targets for drug treatment, develop improved therapies for ALS, and lead clinical research studies performed in numerous medical centers throughout North America.

Joseph (Jody) Puglisi, PhD

 

Dr. Puglisi’s group investigates the role of RNA in cellular processes and disease. Their goal is to understand RNA function in terms of molecular structure and dynamics using a variety of biophysical and biological tools. They use nuclear magnetic resonance (NMR) spectroscopy to determine structures of biological molecules, and integrate structural understanding into further mechanistic and functional studies. They investigate dynamics using single-molecule approaches. Their goal is a unified picture of structure, dynamics and function. They are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections. A long-term goal is to target processes involving RNA with novel therapeutic strategies.

Dr. Puglisi
Dr. Ravits

John Ravits, MD

 

John Ravits, MD, is a board-certified clinical neurologist specializing in amyotrophic lateral sclerosis (ALS), motor neuron diseases, neuromuscular disorders, and clinical neurophysiology. Dr. Ravits is the director of the ALS clinic at UC San Diego Health and vice chair of adult neurology and the neurological sciences. Dr. Ravits is on the editorial board of the medical journal Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. He serves on the scientific advisory committee of the Muscular Dystrophy Foundation, and also serves on the steering committee for the World Federation of Neurology Research Group on Motor Neuron Diseases. As a professor of clinical neuroscience, Dr. Ravits is involved in the training of medical students, residents, and fellows in neurology. His research interests focus on clinical phenotypes, genetic mechanisms especially related to the C9orf72 gene, genomics, antisense oligonucleotide therapies, and molecular neuropathology.